When you take primaquine, a prescription antimalarial drug used to prevent malaria relapse and treat certain types of malaria infections. Also known as an 8-aminoquinoline antimalarial, it works by killing dormant parasites in the liver that other drugs miss. But it’s not harmless—especially if you have a genetic condition called G6PD deficiency. This is the key reason why doctors test for it before prescribing primaquine. If you’re missing this enzyme, the drug can trigger a dangerous drop in red blood cells, leading to hemolytic anemia, a condition where red blood cells break down faster than your body can replace them. It’s not rare, and it’s not theoretical—it happens in real people, often without warning.
Common side effects of primaquine include stomach upset, nausea, dizziness, and headaches. These are usually mild and go away on their own. But some people experience more serious reactions. You might notice dark urine, yellowing skin or eyes, extreme tiredness, or shortness of breath—these are red flags for hemolytic anemia. If you’re from a region where G6PD deficiency is common—like parts of Africa, the Mediterranean, or Southeast Asia—you’re at higher risk. Even if you’ve taken primaquine before without issues, your body can change. That’s why testing isn’t optional; it’s life-saving.
Another thing to watch: primaquine can interact with other medications. If you’re on drugs for heart conditions, depression, or even some antibiotics, it can raise your risk of side effects. Pregnant women should avoid it unless the benefit clearly outweighs the risk. And don’t assume that because it’s used for malaria, it’s safe for travelers just passing through. The risk isn’t about how long you’re abroad—it’s about your biology. Many people don’t know they have G6PD deficiency until they take primaquine. That’s why it’s critical to tell your doctor your full medical history, including any family history of blood disorders.
What you’ll find in the posts below are real, practical guides on how primaquine fits into the bigger picture of antimalarial treatment. You’ll see comparisons with other drugs like chloroquine and tafenoquine, breakdowns of who should avoid it, and what to do if you experience side effects. There’s no fluff—just facts, risks, and clear steps to stay safe. Whether you’re a patient, caregiver, or just trying to understand why your doctor ordered a blood test before prescribing it, this collection gives you the answers without the jargon.
