When you’re dealing with constant heartburn, acid reflux medication, a category of drugs designed to reduce stomach acid and relieve symptoms of gastroesophageal reflux disease. Also known as GERD treatment, it’s one of the most commonly used types of medication in the U.S. But not all of them work the same way, and picking the wrong one can leave you frustrated—and still hurting. Whether you’re reaching for an over-the-counter pill or a prescription, knowing how each type functions can save you time, money, and discomfort.
Proton pump inhibitors, a class of drugs that block the enzyme in your stomach wall that produces acid. Also known as PPIs, they’re the strongest option available and are often prescribed for long-term GERD control. Brands like Prilosec and Nexium fall here, and they’re the go-to for people who get heartburn daily. Then there’s H2 blockers, medications that reduce acid production by targeting histamine receptors in the stomach. Also known as histamine-2 receptor antagonists, these include Zantac and Pepcid—faster-acting than PPIs but usually less powerful over time. If you only get heartburn after big meals or late-night snacks, an H2 blocker might be enough. But if you’ve been using antacids like Tums for years and still feel the burn, you’re likely missing the root cause.
People often mix up acid reflux meds with digestive aids or herbal remedies, but those won’t fix the underlying issue. What works for your neighbor might do nothing for you—because your body, your diet, and your stress levels are different. Some folks need a daily PPI. Others just need to avoid spicy food and sleep propped up. And a surprising number of people are taking acid reflux meds they don’t even need, thanks to overdiagnosis or self-treatment.
Below, you’ll find real comparisons between the most common options, including what side effects to watch for, how long they take to work, and which ones are worth switching from if you’re not seeing results. No marketing fluff. Just what the data and user experiences show.
